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KMID : 0379520030190010051
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한국독성학회지
2003 Volume.19 No. 1 p.51 ~ p.66
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Single and Four-Week Subcutaneous Toxicity Studies of a Bee Venom Extracts (F1, F3) In Rats
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Park Ki-Su
Cho Sung-Dae
Ahn Nam-Shik
Jung Ji-Won
Yang Se-Ran
Park Joon-Suk
Hong In-Sun
Seo Min-Su
Jo Eun-Hye
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Abstract
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This study was performed to evaluate single and repeated-dose toxicities of Bee Venom Extracts (F1, F3) in Spraque-Dawley. F1 was injected subcutaneously to rat at dose levels of 0, 0.0002, 0.002, 0.02 mg/kg/day for single-dose toxicity study and repeated-dose toxicity study. F3 was injected subcutaneously to rat at dose level of 0, 0.003, 0.03, 0.3 mg/kg/day for single-dose toxicity study and repeated-dose toxicity study. In both studies, there were no dose related changes in mortality, clinical sign, body weight change, food and water consumption, opthalmoscopy, organ weights, urine analysis, biochemical examination, and hematological findings of all animals treated with Bee Venom (F1, F3). Gross and histopathological findings revealed no evidence of specific toxicity related to Bee Venom (F1, F3). These results suggest that the subcutaneous NOEL (No Observed Effect Level) of Bee Venom (F1, F3) may be over F1 -0.02 mg/kg, F3-0.3 mg/kg.
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KEYWORD
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Bee venom, Single dose toxicity study, Repeated dose toxicity study, NOEL (No Observed Effect Level), Rats
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